Method for Enhancing Pancreatic Beta Cell Proliferation, Increasing Serum Insulin Concentration, Decreasing Blood Glucose Concentration And Treating And/Or Preventing Diabetes
AssigneeTohoku University
InventorsHideki KATAGIRI, Yoshitomo OKA, Junta IMAI
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Abstract
By enhancing the function of ERK proteins in the liver, proliferation of pancreatic β cells is promoted, blood insulin concentration increased, blood glucose level decreased, and diabetes is prevented and/or treated. The methods for enhancing the function of ERK proteins in the liver are not particularly limited, and include various aspects such as enhancement of activity of MEK proteins, activation of endogenous MEK proteins, administration of an expression vector which expresses a gene encoding an active-form of MEK protein, and the like.
Claims22
A method for promoting proliferation of a pancreatic β cell in a vertebrate, comprising the step of enhancing the function of an ERK protein in the liver of the vertebrate.
A method for increasing blood insulin concentration in a vertebrate, comprising enhancing the function of an ERK protein in the liver of the vertebrate.
A method for decreasing blood glucose level in a vertebrate, comprising enhancing the function of an ERK protein in the liver of the vertebrate.
A method for preventing and/or treating diabetes in a vertebrate, comprising enhancing the function of an ERK protein in the liver of the vertebrate.
A method for stimulating a vagus nerve controlling the pancreas in a vertebrate, comprising enhancing the function of an ERK protein in the liver of the vertebrate.
Dependencies are inferred from the claim text.