Humanized recombinant uricase and mutants thereof
AssigneeCongqing Fagen Biomedical Inc.
InventorsKai Fan, Chun Zhang, Xuefeng Ma, Xiang Mei, Chunlan Hu
Life of this patent
Estimating the term…
Abstract
The present invention provides a humanized recombinant uricase and mutants thereof, wherein the humanized recombinant uricase is a chimeric protein which comprises amino acids of non-human mammal uricase and amino acids of human uricase. The humanized recombinant unease and mutants thereof have reduced immunogenicity in human, and can be used for the treatment of hyperuricemia and gout.
Claims20
A humanized recombinant uricase, wherein the humanized recombinant uricase is a chimeric protein which comprises amino acids of non-human mammal uricase and amino acids of human uricase, or mutants thereof;
- wherein the first 240 amino acids at the N-terminal of said chimeric protein are amino acids 1-240 of non-human mammal uricase and the following 64 amino acids are amino acids 241-304 of human uricase.
Dependencies are inferred from the claim text.