Eutectic-based self-nanoemulsified drug delivery system
AssigneeJarrow Formulas, Inc.
InventorsMansoor A. Khan, Sami Nazzal
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Abstract
A eutectic-based self-nanoemulsified drug delivery system (SNEDDS) is formulated from polyoxyl 35 castor oil (Cremophor), medium chain mono- and diglycerides (capmul), essential oils, and a pharmacologically effective drug. The preferred pharmacologically effective drug is a poorly water soluble drug, such as ubiquinone (CoQ10). The SNEDDS can be further incorporated into a powder to produce a solid dosage form. The solid dosage form contains the SNEDDS, a copolymer of vinylpyrrolidone and vinyl acetate (Kollidon VA 64), maltodextrin, and microcrystalline cellulose (MCC).
Claims22
An orally administered dietary supplement comprising coenzyme Q10, and a sufficient amount of a volatile essential oil to form a solution or oily melt at or below body temperature, and thereby solubilize the ubiquinone comprised in the orally administered dietary supplement at or below body temperature.
An orally administered dietary supplement comprising an amount of coenzyme Q10 sufficient to effectuate a pharmacological effect, and a sufficient amount of a volatile essential oil to form a solution or oily melt at or below body temperature, and thereby solubilize the ubiquinone comprised in the orally administered dietary supplement at or below body temperature, wherein the dietary supplement is comprised within a soft gelatin capsule.
An orally administered dietary supplement comprising coenzyme Q10 and a sufficient amount of a volatile essential oil to solubilize the coenzyme Q10 at or below body temperature, which is produced according to the steps of:
- (a) admixing coenzyme Q10 and a sufficient amount of a volatile essential oil to solubilize the coenzyme Q10 at or below body temperature;
- and
- (b) introducing the mixture from (a) into a hard or soft gelatin capsule, wherein the mixture forms a solution or oily melt at or below body temperature.
Dependencies are inferred from the claim text.