Polypeptides that home to atherosclerotic plaque
AssigneesMedStar Health Research Institute, Inc., Georgetown University
InventorsAnton Wellstein, Stephen E. Epstein, Mary Susan Burnett
Life of this patent
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Abstract
Described herein are homing polypeptides that home to atherosclerotic plaque(s) in mammals and nucleic acids that encode such polypeptides. Also described are methods for detecting and treating conditions or disorders associated with, or characterized, by elevated levels of homing polypeptides that home to atherosclerotic plaque and/or vulnerable plaque.
Claims21
1-57. (canceled)
An isolated homing polypeptide that homes to an atherosclerotic plaque, encoded by a polynucleotide that comprises a sequence selected from the group consisting of:
- SEQ ID NO 24;
- SEQ ID NO 25;
- SEQ ID NO 26;
- SEQ ID NO 27;
- SEQ ID NO 28;
- SEQ ID NO 29;
- SEQ ID NO 30;
- SEQ ID NO 31;
- SEQ ID NO 32;
- SEQ ID NO 33;
- SEQ ID NO 34, SEQ ID NO 35;
- SEQ ID NO 36;
- SEQ ID NO 37, and a sequence that, due to the degeneracy of the genetic code, encodes a polypeptide encoded by any one of SEQ ID NOs:
- 24-37, complements thereof and nucleic acids that hybridize under stringent conditions to the polynucleotide.
A polynucleotide encoding a homing polypeptide, wherein the polynucleotide comprises a sequence selected from the group consisting of:
- SEQ ID NO 24;
- SEQ ID NO 25;
- SEQ ID NO 26;
- SEQ ID NO 27;
- SEQ ID NO 28;
- SEQ ID NO 29;
- SEQ ID NO 30;
- SEQ ID NO 31;
- SEQ ID NO 32;
- SEQ ID NO 33;
- SEQ ID NO 34, SEQ ID NO 35;
- SEQ ID NO 36;
- SEQ ID NO 37, and a sequence that, due to the degeneracy of the genetic code, encodes a polypeptide encoded by any one of SEQ ID NOs 24-37, complements thereof and nucleic acids that hybridize under stringent conditions to the polynucleotide.
A method of determining the risk of a cardiovascular condition in an individual, the method comprising:
- (a) obtaining biological sample from the individual;
- and
- (b) assessing the biological sample for the presence of at least one SNP selected from the group consisting of a SNP shown in Table 1 and a SNP shown in Table 2,
- wherein the presence of the at least one SNP in the biological sample indicates that the individual is at increased risk of a cardiovascular condition.
A method of determining whether an individual is at increased risk of Acute Myocardial Infarction (AMI), the method comprising:
- (a) obtaining a biological sample from the individual;
- and
- (b) assessing the biological sample for the presence of at least one SNP selected from the group consisting of the SNPs shown in Table 3,
- wherein the presence of the at least one SNP in the biological sample indicates that the individual has an increased risk of AMI, and
- wherein the greater the number of SNPs in the biological sample, the greater the risk of AMI in the individual.
A method of determining an increased risk of Coronary Artery Disease (CAD) in an individual, the method comprising:
- (a) obtaining a biological sample from the individual;
- and
- (b) determining the presence in the biological sample of at least one SNP selected from the group consisting of the SNPs shown in Table 6,
- wherein the presence of the at least one SNP indicates that the individual has an increased risk of CAD, and
- wherein the greater number of SNPs in the biological sample, the greater the risk of CAD in the individual.
A method of assessing risk for coronary artery disease (CAD) in an individual, comprising:
- (a) developing a genetic risk score (GRS) for the individual;
- and
- (b) comparing the genetic risk score for the individual with an appropriate reference,
- wherein the genetic risk score is developed in (a) by determining the number of risk alleles the individual has and wherein the appropriate reference is a reference genetic risk score.
The method of 73, wherein the number of risk alleles the individual has is determined by assessing a sample obtained from the individual for at least one SNP associated with acute CAD or myocardial infarction;
- at least one SNP associated with stable CAD;
- or at least one SNP associated with acute CAD or myocardial infarction and at least one SNP associated with stable CAD.
Dependencies are inferred from the claim text.