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US 2012/0269723 A1Published application
Complex of bi-specific antibody and digoxigenin conjugated to a therapeutic or diagnostic agent
AssigneeHoffmann-La Roche Inc.
InventorsUlrich Brinkmann, Rebecca Croasdale, Wilma Dormeyer, Guy Georges, Alexander Haas, Eike Hoffman, Silke Metz, Olaf Mundigl, Werner Scheuer, Jan Olaf Stracke
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Abstract
The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
Claims23
A complex comprising:
- a bi-specific antibody specific against digoxigenin (DIG) and a target protein, comprising a first antigen-binding site that binds to the digoxigenin and a second antigen-binding site that binds to the target protein, wherein the digoxigenin is conjugated to a therapeutic or a diagnostic agent selected from the group consisting of a peptide, a small compound, a radioactively labeled small compound, and an imaging reagent.
-25. (canceled)
Dependencies are inferred from the claim text.