Back to results
US 2012/0267255 A1Published application
Electrochemical system and method thereof
AssigneeCleveland State University
InventorSiu-Tung Yau
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeCleveland State University
InventorSiu-Tung Yau
Estimating the term…
An embodiment of the invention provides an ultrasensitive and selective system and method for detecting reactants of the chemical/biochemical reaction catalyzed by an oxidoreductase, such as glucose and ethanol, at a concentration level down to zepto molar (10−21 M). In embodiments, the invention provides an ampyometric immuno-sensing system comprising a working electrode, an oxidoreductase, and an external voltage generator, wherein the oxidoreductase is immobilized on the working electrode; and the voltage generator generates a voltage to induce an electric field that permeates at least a portion of the interface between the oxidoreductase and the working electrode. The ultrasensitivity of the system and method is believed to be caused by the electrical field, which enhances the quantum mechanical tunneling effect in the interface, and therefore facilitates the interfacial electron transfer between the oxidoreductase and the working electrode.
An amperometric immuno-sensing system embodied in the form of an electrochemical cell, which can be used to perform cyclic voltammetry and amperometry, the system comprising a working electrode, an oxidoreductase, and an external voltage generator, wherein the oxidoreductase is immobilized on the working electrode via an antibody-antigen-antibody sandwich structure that is immobilized on the working electrode;
A cyclic voltammetry/amperometry system comprising a working electrode, a reference electrode, a counter electrode, an oxidoreductase, and an additional electrode, wherein the oxidoreductase is immobilized on the working electrode;
A method of detecting the reactant of a chemical reaction catalyzed by an oxidoreductase, comprising using a cyclic voltammetry system comprising a working electrode, a reference electrode, a counter electrode, an oxidoreductase, and an additional electrode, wherein the oxidoreductase is immobilized on the working electrode;
An electrochemical method for enhancing the electrical charge flow across the interface between a solution and an electrode on its surface, which comprises using an external electric field applied to the interface.
Dependencies are inferred from the claim text.