Methods and apparatus for improving the sensitivity of capillary zone electrophoresis
AssigneeBeckman Coulter, Inc.
InventorsChitra Kumari Ratnayake, Michael Paul Henry
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Abstract
The present invention relates to novel methods and apparatus for improving the sensitivity of capillary zone electrophoresis (CZE). The invention particularly concerns devices comprising a channel that contains an in-line sol-gel column to concentrate samples being subjected to capillary zone electrophoresis, and the use of such devices to enhance the sensitivity of capillary zone electrophoresis.
Claims24
A sol-gel concentrating device comprising a channel containing a column of a monolith of a polymerized alkylsilicate gel matrix containing chromatographic sorbent particles, wherein said gel matrix is polymerized under conditions sufficient to permit evaporation of solvent without substantial destabilization of said monolith.
A method for concentrating an analyte in a sample being subjected to an analytical or preparative process, wherein said method comprises concentrating said analyte using a sol-gel concentrating device, said device comprising a channel containing a column of a monolith of a polymerized alkylsilicate gel matrix containing chromatographic sorbent particles, wherein said gel matrix is polymerized under conditions sufficient to permit evaporation of solvent without substantial destabilization of said monolith.
Dependencies are inferred from the claim text.