Chemically Amplified Response Strategies for Medical Sciences
AssigneeThe Regents of the University of California
InventorsAdah Almutairi, Nadezda Fomina, Jagadis Sankaranarayanan
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Abstract
Compositions are provided in which dendrimers and/or nanoparticles are synthesized with multi-photon responsive elements and self-immolative oligomers. The compositions may be utilized to selectively deliver Payloads within tissue by irradiating the compositions. The compositions may also be used to amplify sensitivity to irradiation.
Claims23
A composition comprising a multi-photon responsive element covalently linked to a self-immolative backbone subunit.
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A method delivering a Payload to a tissue comprising the steps of:
- synthesizing a particle wherein said particle further comprises a multi-photon responsive element, a self-immolative backbone subunit, a molecular network, and a Payload;
- administering said particle to said tissue;
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- irradiating said tissue comprising said particle with electromagnetic radiation;
- wherein said particle is disrupted in situ following absorption of said electromagnetic radiation.
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Dependencies are inferred from the claim text.