System and method of measuring changes in arterial volume of a limb segment
AssigneeAngiologix, Inc.
InventorsAlexander S. Parfenov, Maria A. Parfenova, Nikolay Vasilyevich Konstantinov
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Abstract
A medical diagnostic device performs diagnostics for assessing the ability of the arteries to respond to an increase in blood flow. The medical diagnostic device determines relative changes in arterial volume of the limb segment during a time period after a stimulus relative to the arterial volume of the limb segment during a baseline period using the amplitudes or other portions of the component pulse waves (such as early systolic components) of volume pulse waves during the baseline period and after the stimulus.
Claims21
A method of assessing a relative change in arterial volume of a limb segment of a mammal, the method comprising:
- detecting a baseline volume pulse wave associated with a limb segment of a mammal during a baseline period;
- determining an amplitude of an early systolic component of the baseline volume pulse wave;
- applying a stimulus to induce a change in the arterial volume of the limb segment;
- detecting an after-stimulus volume pulse wave associated with the limb segment during an after-stimulus period;
- determining an amplitude of an early systolic component of the after-stimulus volume pulse wave;
- and
- assessing a relative change in arterial volume of the limb segment from the baseline period to the after-stimulus period using the amplitude of the early systolic component of the baseline volume pulse wave and the amplitude of the early systolic component of the after-stimulus volume pulse wave.
A diagnostic system for assessing a change in arterial volume of a limb segment of a mammal, the diagnostic system comprising:
- a sensor configured to detect a baseline volume pulse wave of a limb segment during a baseline period and an after-stimulus volume pulse wave of the limb segment during an after-stimulus period, the sensor being configured to operatively engage the limb segment at a position proximal from individual digits of the limb;
- and
- a processer operatively coupled to the sensor, the processor being configured to determine an amplitude of an early systolic component of the baseline volume pulse wave, an amplitude of an early systolic component of the after-stimulus volume pulse wave, and a change in arterial volume of the limb segment from the baseline period to the after-stimulus period using the amplitude of the early systolic component of the baseline volume pulse wave and the amplitude of the early systolic component of the after-stimulus volume pulse wave.
A non-transitory, machine-readable medium encoded with instructions that, when executed by one or more processors, cause the processor to carry out a process for assessing change in arterial volume of a limb segment of a mammal, the process comprising:
- determining an amplitude of an early systolic component of a baseline volume pulse wave associated with a limb segment of a mammal during a baseline period;
- determining an amplitude of an early systolic component of an after-stimulus volume pulse wave associated with the limb segment during an after-stimulus period;
- and
- assessing a relative change in arterial volume of the limb segment from the baseline period to the after-stimulus period using the amplitude of the early systolic component of the baseline volume pulse wave and the amplitude of the early systolic component of the after-stimulus volume pulse wave.
Dependencies are inferred from the claim text.