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US 2012/0259200 A1Published application
Method for Monitoring Early Treatment Response
AssigneeReceptomon, LLC
InventorJoseph F. Norfray
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AssigneeReceptomon, LLC
InventorJoseph F. Norfray
Estimating the term…
Disclosed is a method for monitoring early treatment response of a cancer treatment comprising measuring by magnetic resonance spectroscopy (MRS), for example, 1H MRS, the amount of saturated and unsaturated fatty acids present in the intracellular membranes of the cancerous tissue before and after treatment, whereby an increase in the amount of saturated and unsaturated fatty acids after treatment is indicative of a positive response from interruption of protein translation. The increase in the amount of saturated and unsaturated fatty acids represents the degradation in the internal cell membrane as a result of down regulation of the organelles and their secretory granules and their transport vesicles. Disclosed also is a method for determining effectiveness of a cancer treatment to induce apoptosis from interruption of protein translation in an animal having a cancerous tissue by MRS.
A method for monitoring early treatment response of a cancer treatment comprising measuring non-invasively, by magnetic resonance spectroscopy (MRS), the amount of saturated and/or unsaturated fatty acids present in the cancerous tissue before and after treatment, determining whether the amount of saturated and/or unsaturated fatty acids have increased, decreased, or remained the same, and correlating an increase in the amount of saturated and unsaturated fatty acids after treatment to a positive response resulting from interruption of protein translation due to the treatment.
16-29. (canceled)
A method for monitoring cancer treatment comprising:
31-32. (canceled)
A method for determining effectiveness of a molecule as a drug for treating cancer comprising administering an amount of the molecule to an animal having a cancerous tissue and measuring non-invasively, by Magnetic Resonance Spectroscopy, the amount of saturated/unsaturated fatty acids present in the cancerous tissue before and within a period of about 168 hours after administering the molecule, obtaining a difference between the saturated/unsaturated fatty acids amounts, and correlating the increase in the saturated/unsaturated fatty acids amounts with effectiveness of the cancer treatment or lack thereof.
A method for monitoring interruption of protein translation in an animal having a cancerous tissue comprising administering a cancer therapy to the animal and measuring, by Magnetic Resonance Spectroscopy, the amount of saturated/unsaturated fatty acids present in the intracellular membranes of the cancerous tissue before and after administering the cancer therapy, obtaining a difference between the amounts of saturated/unsaturated fatty acids, and correlating the increase to interruption of protein translation.
A method for determining the effectiveness of a cancer treatment to induce apoptosis from interruption of protein translation in an animal having a cancerous tissue comprising administering an amount of the molecule to an animal having a cancerous tissue and measuring non-invasively, by Magnetic Resonance Spectroscopy, the amount of saturated/unsaturated fatty acids present in the cancerous tissue before and within a period of about 168 hours after administering the molecule, obtaining a difference between the saturated/unsaturated fatty acids amounts, and correlating the increase in the saturated/unsaturated fatty acids amounts with effectiveness of the cancer treatment or lack thereof.
Dependencies are inferred from the claim text.