Back to results
US 2012/0259150 A1Published application
Compositions and Methods of Sphingosine Kinase Inhibitors In Radiation Therapy of Various Cancers
AssigneeUniversity of Southern California
InventorsUttam K. SINHA, Rizwan MASOOD
Life of this patent
Estimating the term…
Abstract
The present invention relates to Sphingosine kinase inhibitors that are useful for treating various cancers. The invention further relates to compositions and methods of SPK inhibitors, including siRNAs, which specifically block gene expression of SPK and potentiates the effect of radiation in the treatment of various cancers.
Claims19
1-22. (canceled)
A method of treating cancer in a subject, comprising:
- administering to cancer cells in said subject a siRNA inhibitor in an amount sufficient to block the expression of sphingosine kinase 1 (SPK1) in the cancer cells and potentiate an effect of radiation, wherein the siRNA comprises a sense sequence and an antisense sequence, and the antisense sequence is complementary to an mRNA encoding SPK1, and
- administering radiation to the subject in an amount greater than or equal to 100 rads and less than or equal to 500 rads during the time period the effect of the radiation is potentiated by blocking expression of SPK1.
A method of treating head and/or neck cancer in a subject, comprising:
- administering to head and/or neck cancer cells in the subject a siRNA inhibitor in an amount sufficient to block the expression of sphingosine kinase 1 (SPK1) in the cancer cells and potentiate an effect of radiation, wherein the siRNA comprises a sense sequence and an antisense sequence, and the antisense sequence is complimentary to an mRNA encoding SPK1, and
- administering radiation to the subject in an amount greater than or equal to 100 rads and less than or equal to 500 rads at a time when the effect of the radiation is potentiated by blocking expression of SPK1.
A method of treating cancer in a subject, comprising:
- administering to cancer cells in said subject a siRNA inhibitor in an amount sufficient to block the expression of sphingosine kinase 1 (SPK1) in the cancer cells and potentiate an effect of radiation, wherein the siRNA comprises a sense sequence and an antisense sequence, and the antisense sequence is complementary to an mRNA encoding SPK1, and
- administering radiation to the subject in an amount greater than or equal to 100 rads and less than or equal to 500 rads.
A method of treating cancer in a subject, comprising:
- administering to cancer cells in said subject a siRNA inhibitor in an amount sufficient to block the expression of sphingosine kinase 1 (SPK1) in the cancer cells and potentiate an effect of radiation, wherein the siRNA comprises a sense sequence and an antisense sequence, and the antisense sequence is complementary to an mRNA encoding SPK1, and
- administering radiation to the subject.
Dependencies are inferred from the claim text.