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US 2012/0259116 A1Published application
Novel Process for the Preparation of Paliperidone
OwnerRajiv Kumar, Dharmesh Kumar Arvindbhaipatel +4inventors
InventorsRajiv Kumar, Dharmesh Kumar Arvindbhaipatel, Dattatray Shamrao Metil, Praveen Raosaheb Supekar, Prashant Pandurangpawar, Santosh Vitthal Pune
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Abstract
The present invention relates to a novel process for the preparation of paliperidone by hydrolysis of 9-O-acylated paliperidone. In a preferred embodiment of the present invention, Paliperidone Form (II) of purity of about 98% or more was obtained by basic hydrolysis of 9-O-Acetyl Paliperidone.
Claims8
A process for the preparation of palipieridone comprising hydrolysis of 9-O-acylated Paliperidone of Formula
- wherein R=C1-C10 straight or branched alkyl, alkyl substituted by aryl or aryl which may be unsubstituted or substituted.
Dependencies are inferred from the claim text.