Methods for the synthesis of polycyclic guanidine compounds
AssigneeNovomer, Inc.
InventorAlexei Gridnev
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Abstract
The present invention provides methods for the synthesis of polycyclic guanidine compounds. In certain embodiments, provided methods include the step of contacting a described reagent with a triamine compound to provide a polycyclic guanidine compound.
Claims69
A method for the preparation of a polycyclic guanidine compound comprising the step of contacting a triamine compound with a reagent selected from the group consisting of guanidine, acyclic guanidine compounds, cyanamide, cyanimide compounds, melamine and melamine derivatives.
A method of synthesizing 1,5,7-triazabicyclo[5.5.0]dece-5-ene (TBD) comprising the step of contacting guanidine carbonate with bis(3-aminopropyl)amine in the presence of a sulfonic acid.
A method of synthesizing 1,5,7-triazabicyclo[5.5.0]dece-5-ene (TBD) comprising the step of contacting tetramethylguanidine with bis(3-aminopropyl)amine in the presence of a sulfonic acid.
Dependencies are inferred from the claim text.