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US 2012/0259104 A1Published application
Self-amplifying folded oligonucleotide structure
AssigneeKorea University Research and Business Foundation
InventorHong Gu Chun
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Abstract
The present invention relates to a self-amplifying folded oligonucleotide structure for sensitive oligonucleotide sensing without polymerase chain reaction (PCR). A self-amplifying folded oligonucleotide structure comprise a target sensing sequence having stem loop structure, a signaling molecule and signal modifying molecule labeled two stems wherein the two stems include oligonucleotide sequence that is complementary to a target sensing sequence of another self-amplifying folded oligonucleotide structure.
Claims7
A self-amplifying folded oligonucleotide structure comprising:
- a) a target sensing sequence having stem loop structure;
- and
- b) two stems wherein one is labeled with a signaling molecule and the other one is labeled with a signal modifying molecule,
- wherein the two stems include oligonucleotide sequence that is complementary to a target sensing sequence of another self-amplifying folded oligonucleotide structure.
1 more element
Dependencies are inferred from the claim text.