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US 2012/0259092 A1Published application
Npy antagonists
OwnerDavid Chatenet, Jean Claude Reubi +1inventors
InventorsDavid Chatenet, Jean Claude Reubi, Jean E. F. Rivier
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Abstract
Peptidic NPY antagonists selective for Y1 having an organic chelator, such as DOTA, coupled thereto which are useful for diagnostic procedures and receptor-mediated radiotherapy.
Claims19
A peptide having the formula:
- where each Xaa2 is independently Lys, Hly, Orn, Dbu, Dpr or Asn;
- each Xaa4 is independently Cys, Hcy, Ncy, Glu, Asp, Lys, Orn or Dpr
- each Xaa5 is independently Trp or an aromatic L-amino acid, and each Xaa7 is independently Nle or Nva;
- wherein only one of the Xaa2 residues is coupled to an organic chelator via its sidechain primary amino group.
1 more element
A peptide having the formula:
A peptide having the formula:
Dependencies are inferred from the claim text.