Treatment for Amyotrophic Lateral Sclerosis
AssigneeBiogen Idec MA Inc.
InventorMatvey E. LUKASHEV
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Abstract
Provided are certain methods of screening, identifying, and evaluating neuroprotective compounds useful for treatment of neurological diseases, such as, e.g., multiple sclerosis (MS). The compounds described upregulate the cellular cytoprotective pathway regulated by Nrf2. Also provided are certain methods of utilizing such compounds in therapy for neurological disease, particularly, for slowing or reducing demyelination, axonal loss, or neuronal and oligodendrocyte death.
Claims14
-17. (canceled)
A method of treating amyotrophic lateral sclerosis (ALS), comprising orally administering to a subject in need of such treatment a therapeutically effective amount of dimethyl fumarate (DMF), monomethyl fumarate (MMF), or a combination thereof.
A method of treating amyotrophic lateral sclerosis (ALS), comprising orally administering to a subject in need of such treatment a therapeutically effective amount of DMF.
Dependencies are inferred from the claim text.