New application of 2-pyrrolidone derivatives

A method of inhibiting protein glycation comprising contacting the protein with a 2-pyrrolidone derivative selected from the group consisting of:

• a) compound of general formula I:
• in which R1, R2 are:
• hydrogen atom or halogen atom or amino group (—NH2), hydroxyl group (—OH), linear or branched C1-5 alkyl groups, linear or branched C1-4 alkyl-amino groups or guanidine group,
• R3 is:
• hydrogen atom or halogen atom or amino group (—NH2), hydroxyl group (—OH), linear or branched C1-5 alkyl groups, linear or branched C1-4 alkyl-amino groups or guanidine group, phenyl group (C6H5—) or phenyl group substituted by one or more hydroxyl, methyl, amino, alkyl-amino groups or halogen atoms,
• b) compound of general formula II:
• in which R1, R2 mean as above, while R4 means C6H4—OCH3 group,
• c) compound of general formula III:
• in which R1 means as above, while R5 means C6H5 group, and mixtures thereof.

A method of preventing or treating diabetes complications in a subject, comprising administering to the subject

• a) a compound of general formula I:
• in which R1, R2 are:
• hydrogen atom or halogen atom or amino group (—NH2), hydroxyl group (—OH), linear or branched alkyl groups, linear or branched C1-4 alkyl-amino groups or guanidine group,
• R3 is:
• hydrogen atom or halogen atom or amino group (—NH2), hydroxyl group (—OH), linear or branched C1-5 alkyl groups, linear or branched C1-4 alkyl-amino groups or guanidine group, phenyl group (C6H5—) or phenyl group substituted by one or more hydroxyl, methyl, amino, alkyl amino groups or halogen atoms,
• b) a compound of general formula II:
• in which R1, R2 mean as above, while R4 means C6H4—OCH3 group, or
• c) a compound of general formula III:
• in which R1 means as above, while R5 means C6H5 group.