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US 2012/0258987 A1Published application
Lysophosphatidic acid receptor antagonists
AssigneeAmira Pharmaceuticals, Inc.
InventorsThomas Jon Seiders, Jeffrey Roger Roppe, Timothy Andrew Parr
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Abstract
Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
Claims19
A compound having the structure of Formula (I), or N-oxide, or a pharmaceutically acceptable salt thereof:
- wherein,
- R1 is
- and R3 is H or C1-C4alkyl;
- or R1 is H or C1-C4alkyl and R3 is
- R2 is —OH, —OC1-C4alkyl, or —NHSO2R7;
- R7 is C1-C4alkyl or a substituted or unsubstituted phenyl;
- R4 is absent or —OH;
- R5 is absent or —OH;
- each R6 is independently C1-C4alkyl, C1-C4deuteroalkyl, C1-C4monofluoroalkyl, C1-C4difluoroalkyl, or C3-C6cycloalkyl;
- ring A is a substituted or unsubstituted monocyclic six-membered C3-C5heteroarylene, where if ring A is substituted, then ring A is substituted with 1 or 2 RA, each RA is independently halogen, —OH, C1-C4alkyl, C1-C4fluoroalkyl, C1-C4deuteroalkyl, or C1-C4alkoxy;
- m is 1 or 2;
- n is 1, 2, 3, or 4.
9 more elements
Dependencies are inferred from the claim text.