Disubstituted heteroaryl-fused pyridines

A compound of formula I′

• wherein
• Q1 is —N(R1)—;
• wherein R1 is hydrogen;
• C1-6alkyl;
• C1-6halogenalkyl;
• C2-6alkenyl;
• C2-6halogenalkenyl;
• C2-6alkynyl;
• C2-6halogenalkynyl;
• a three- to eight-membered monocyclic or bicyclic saturated or unsaturated non-aromatic ring system which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may contain not more than 2 oxygen atoms and not more than 2 sulfur atoms, wherein the ring system may be attached directly or via a C1-4alkylene group, and wherein the ring system may be substituted once or more than once by R8, and wherein a substituent on a nitrogen in a heterocyclic ring system may not be halogen;
• and
• R2 is C2-6alkyl;
• C2-6halogenalkyl;
• C2-6alkenyl;
• C2-6halogenalkenyl;
• C2-6alkynyl;
• C2-6halogenalkynyl;
• or R2 is a three- to eight-membered monocyclic or bicyclic saturated or unsaturated non-aromatic ring system which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may contain not more than 2 oxygen atoms and not more than 2 sulfur atoms, wherein the ring system may be attached directly or via a C1-4alkylene group, and wherein the ring system may be substituted once or more than once by R9, and wherein a substituent on a nitrogen in a heterocyclic ring system may not be halogen;
• or R2 is a five- to six-membered monocyclic aromatic ring system which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may contain not more than 2 oxygen atoms and not more than 2 sulfur atoms, wherein the ring system may be attached directly or via a C1-4alkylene group, and wherein the ring system may be substituted once or more than once by R10, and wherein a substituent on a nitrogen in a heterocyclic ring system may not be halogen;
• or
• wherein R1 is a five- to six-membered monocyclic aromatic ring system which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may contain not more than 2 oxygen atoms and not more than 2 sulfur atoms, wherein the ring system may be attached directly or via a C1-4alkylene group, and wherein the ring system may be substituted once or more than once by R11, and wherein a substituent on a nitrogen in a heterocyclic ring system may not be halogen;
• and
• R2 is C2-6alkyl;
• C2-6halogenalkyl;
• C2-6alkenyl;
• C2-6halogenalkenyl;
• C2-6alkynyl;
• C2-6halogenalkynyl;
• or R2 is a three- to eight-membered monocyclic or bicyclic saturated or unsaturated non-aromatic ring system which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may contain not more than 2 oxygen atoms and not more than 2 sulfur atoms, wherein the ring system may be attached directly or via a C1-4alkylene group, and wherein the ring system may be substituted once or more than once by R12, and wherein a substituent on a nitrogen in a heterocyclic ring system may not be halogen;
• each R8 independently is halogen, C1-6alkyl, C1-6halogenalkyl, C3-7cycloalkyl, C3-7cycloalkyl(C1-4alkyl), C1-6alkoxy, or C1-6halogenalkoxy;
• or two R8 at the same ring atom together are oxo;
• each R9 independently is halogen, C1-6alkyl, C1-6halogenalkyl, C3-7cycloalkyl, C3-7cycloalkyl(C1-4alkyl), C1-6alkoxy, or C1-6halogenalkoxy;
• or two R9 at the same ring atom together are oxo;
• each R12 independently is halogen, C1-6alkyl, C1-6halogenalkyl, C3-7cycloalkyl, C3-7cycloalkyl(C1-4alkyl), C1-6alkoxy, or C1-6halogenalkoxy;
• or two R12 at the same ring atom together are oxo;
• each R10 independently is halogen, C1-6alkyl, C1-6halogenalkyl, C3-7cycloalkyl, C3-7cycloalkyl(C1-4alkyl), C1-6alkoxy, or C1-6halogenalkoxy;
• or two R10 at adjacent ring atoms form together with said ring atoms a fused five- to seven-membered unsaturated non-aromatic ring system which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may contain not more than 2 oxygen atoms and not more than 2 sulfur atoms, and wherein the ring system may in turn be substituted once or more than once by R13, and wherein a substituent on a nitrogen in a heterocyclic ring system may not be halogen;
• and wherein each R13 independently is halogen or C1-6alkyl, or two R13 at the same ring atom together are oxo;
• each R11 independently is halogen, C1-6alkyl, C1-6halogenalkyl, C3-7cycloalkyl, C3-7cycloalkyl(C1-4alkyl), C1-6alkoxy, or C1-6halogenalkoxy;
• or two R11 at adjacent ring atoms form together with said ring atoms a fused five- to seven-membered unsaturated non-aromatic ring system which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may contain not more than 2 oxygen atoms and not more than 2 sulfur atoms, and wherein the ring system may in turn be substituted once or more than once by R14, and wherein a substituent on a nitrogen in a heterocyclic ring system may not be halogen;
• and wherein each R14 independently is halogen or C1-6alkyl, or two R14 at the same ring atom together are oxo;
• or
• Q1 is —O— and
• R2 is C2-6alkyl;
• C2-6halogenalkyl;
• C2-6alkenyl;
• C2-6halogenalkenyl;
• C2-6alkynyl;
• C2-6halogenalkynyl;
• or R2 is a three- to eight-membered monocyclic or bicyclic saturated or unsaturated non-aromatic ring system which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may contain not more than 2 oxygen atoms and not more than 2 sulfur atoms, wherein the ring system may be attached directly or via a C1-4alkylene group, and wherein the ring system may be substituted once or more than once by R9a, and wherein a substituent on a nitrogen in a heterocyclic ring system may not be halogen;
• or R2 is a five- to six-membered monocyclic aromatic ring system which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may contain not more than 2 oxygen atoms and not more than 2 sulfur atoms, wherein the ring system may be attached directly or via a C1-4alkylene group, and wherein the ring system may be substituted once or more than once by R10a, and wherein a substituent on a nitrogen in a heterocyclic ring system may not be halogen;
• each R9a independently is halogen, C1-6alkyl, C1-6halogenalkyl, C3-7cycloalkyl, C3-7cycloalkyl(C1-4alkyl), C1-6alkoxy, or C1-6halogenalkoxy;
• or two R9a at the same ring atom together are oxo;
• each R10a independently is halogen, C1-6alkyl, C1-6halogenalkyl, C3-7cycloalkyl, C3-7cycloalkyl(C1-4alkyl), C1-6alkoxy, or C1-6halogenalkoxy;
• or two R10a at adjacent ring atoms form together with said ring atoms a fused five- to seven-membered unsaturated non-aromatic ring system which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may contain not more than 2 oxygen atoms and not more than 2 sulfur atoms, and wherein the ring system may in turn be substituted once or more than once by R13a, and wherein a substituent on a nitrogen in a heterocyclic ring system may not be halogen;
• and wherein each R13a independently is halogen or C1-6alkyl, or two R13a at the same ring atom together are oxo;
• Q2 is ═N— or ═C(R1a)—;
• wherein R1a is hydrogen;
• C1-6alkyl;
• Cl1-6halogenalkyl;
• C2-6alkenyl;
• C2-6halogenalkenyl;
• C2-6alkynyl;
• C2-6halogenalkynyl;
• R3 and R4 are each independently selected from hydrogen, halogen, hydroxyl, C1-6alkyl, C1-6halogenalkyl, C1-6alkoxy, C1-6halogenalkoxy, C2-6alkenyl, C2-6halogenalkenyl, C2-6alkinyl, C2-6halogenalkinyl, C3-7cycloalkyl, C3-7cycloalkyl(C1-4alkyl);
• X1 is —O—, —N(R15)—;
• R15 is hydrogen or C1-6alkyl;
• n is 1, 2 or 3;
• each R5 independently is selected from hydrogen, halogen, hydroxyl, C1-6alkyl, C1-6halogenalkyl, C1-6alkoxy, C1-6halogenalkoxy, C3-7cycloalkyl, C3-7cycloalkyl(C1-4alkyl);
• or two R5 at the same carbon atom together with said carbon atom form C3-7cycloalkyl;
• or two R5 at adjacent carbon atoms together with said carbon atoms form C3-7cycloalkyl;
• or two R5 at carbon atoms separated by one further carbon atom together with said carbon atoms form C4-7cycloalkyl;
• Z1 is —C(O)—, —S(O)— or —S(O)2—;
• R6 is C1-6 alkyl, C1-6halogenalkyl, C2-6alkenyl, C2-6halogenalkenyl, C2-6alkynyl, C2-6halogenalkynyl, C3-7cycloalkyl, C3-7cycloalkyl(C1-4alkyl) or a five- to ten-membered monocyclic or fused polycyclic aromatic ring system which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may contain not more than 2 oxygen atoms and not more than 2 sulfur atoms, wherein the ring system is attached to the nitrogen atom via a C1-4 alkylene group, and wherein the ring system may be substituted once or more than once by R16, and wherein a substituent on a nitrogen in a heterocyclic ring system may not be halogen;
• each R16 independently is halogen, C1-6alkyl, C1-6halogenalkyl, C3-7cycloalkyl, C3-7cycloalkyl(C1-4alkyl), C1-6alkoxy, or C1-6halogenalkoxy;
• or two R16 at adjacent ring atoms form together with said ring atoms a fused five- to seven-membered unsaturated non-aromatic ring system which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may contain not more than 2 oxygen atoms and not more than 2 sulfur atoms, and wherein the ring system may in turn be substituted once or more than once by R17, and wherein a substituent on a nitrogen in a heterocyclic ring system may not be halogen;
• and wherein each R17 independently is halogen or C1-6alkyl, or two R17 at the same ring atom together are oxo;
• or
• R6 is a group A
• wherein
• p is 1 or 2;
• q is 0, 1, 2, 3 or 4;
• each R18 independently is halogen or C1-6alkyl;
• A1 is a five- to six-membered monocyclic aromatic ring system which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may contain not more than 2 oxygen atoms and not more than 2 sulfur atoms, wherein the ring system may be substituted once or more than once by R19, and wherein a substituent on a nitrogen in a heterocyclic ring system may not be halogen;
• each R19 independently is halogen, C1-6alkyl, C1-6halogenalkyl, C3-7cycloalkyl, C3-7cycloalkyl(C1-4alkyl), C1-6alkoxy, or C1-6halogenalkoxy;
• and R7 is hydrogen, C1-6alkyl, C1-6halogenalkyl, C2-6alkenyl, C2-6halogenalkenyl, C2-6alkinyl, C2-6halogenalkinyl, C3-7cycloalkyl, C3-7cycloalkyl(C1-4alkyl);
• in free form or in salt form.