4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity

A compound of general formula (I) and pharmaceutically acceptable salts and solvates thereof

• wherein
• R1 is
• halogen;
• vinylene-aryl;
• aryl, which may be substituted with one or more substituent selected from the following group:
• alkoxy which is optionally substituted with one or more halogen or with aryl which is optionally substituted with one or more halogen, alkyl or alkoxy, preferably with alkoxy,
• halogen,
• alkyl which is optionally substituted with one or more halogen or alkoxy, preferably with halogen,
• alkylaryloxy which is optionally substituted with alkoxy which is optionally substituted with one or more halogen,
• aminocarbonyl,
• amino, which is optionally substituted with one or two alkyl;
• alkylthio,
• alkylsulfinyl or alkylsulfonyl,
• aryloxy,
• hydroxyl;
• group of formula (a)
• wherein m is 1, 2 or 3 and R′ is hydrogen, halogen, alkyl or alkoxy;
• heteroaryl;
• W is a
• group of formula (b)
• wherein R2 stands for
• alkyl, alkoxy or aryl, which groups are optionally substituted with one or more halogen,
• heteroaryl,
• benzyl, which is optionally substituted with one or more halogen, alkyl or alkoxy,
• amino, which is optionally substituted with one or two alkyl;
• heteroaryl group, which is optionally substituted with a (CH2)k-heterocycloalkyl group, where k is 0, 1, 2 or 3;
• NH—R3, wherein R3 is hydrogen, alkyl, alkoxy, aryl, aryloxy, heteroaryl, heteroaryloxy, aminoalkyl, aminoaryl or aminoheteroaryl;
• and
• n is 1, 2, 3 or 4.