Use of a spirolide, analogues and derivatives for treating and/or preventing pathological conditions linked to the tau and beta-amyloid proteins
OwnerLuis M. Botana López, Eva Alonso López +1inventors
InventorsLuis M. Botana López, Eva Alonso López, Carmen Vale González
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Abstract
The present invention is in the field of biomedicine. Specifically, it relates to the use of a spirolide compound with the chemical structure: for preparing a drug for the prevention and/or treatment of a pathology related to the increase in β-amyloid protein and/or hyperphosphorylation of tau protein compared to control, where said spirolide compound is administered in the amount necessary to reach a concentration in the serum of equal to or less than 50 nM. The amount administered is preferably the amount necessary to reach a concentration in the serum of between 0.5 nM and 50 nM.
Claims12
A method for the prevention and/or treatment of a pathology related to the increase in β-amyloid protein and/or hyperphosphorylation of the tau protein compared to control, comprising administering in the amount necessary to reach a concentration in the serum of equal to or less than 50 nM to a patient in need thereof a spirolide compound of chemical structure (I)
- wherein:
- R1 can be hydrogen or an alkyl group (C1-C4),
- R2 can be hydrogen or an alkyl group (C1-C4),
- if C33 is not linked to X and X is O, R3 is NH2 and
- if C33 is linked to X, then R3 is H and X is N.
Dependencies are inferred from the claim text.