Substituted N-(1H-Indazol-4-yl)Imidazo[1,2-a]Pyridine-3-Carboxamide Compounds as cFMS Inhibitors

A compound having the general formula I

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is hetAr1CH2—, hetAr2CH2—, (3-6C cycloalkyl)-CH2—, tetrahydropyranylCH2—, benzyl which is optionally substituted with (1-4C)alkoxy, or (N-1-3C alkyl)pyridinonyl-CH2— which is optionally substituted with one or more substituents independently selected from (1-6C)alkyl;
• hetAr1 is pyridyl optionally substituted with one or more substituents independently selected from (1-6C)alkyl, (1-4C)alkoxy, halogen, hetCyc1, hetCyc1-CH2—, amino(2-4C)alkoxy, [di(1-3C alkyl)amino](2-4C)alkoxy, dihydroxy(3-4C)alkoxy, hetCyc2O—, hetCyc2a(1-2 C)alkoxy and OH;
• hetCyc1 is a 6-membered heterocycle having 1-2 ring N atoms and optionally substituted with NH2;
• hetCyc2 and hetCyc2a are independently a 5-6 membered heterocycle having 1-2 ring N atoms and optionally substituted with one or more substituents independently selected from (1-6C)alkyl, OH, and halogen;
• hetAr2 is a 5-membered heteroaryl ring having 2-3 ring heteroatoms independently selected from N, S and O where at least one of said heteroatoms is N, wherein said ring is optionally substituted with one or more substituents independently selected from (1-6C)alkyl, (2-4C)hydroxyalkyl, (3-4C)dihydroxyalkyl, (3-6C cycloalkyl)CH2—, hetCyc3, hetCyc3a(1-2C)alkyl, and benzyl optionally substituted with (1-4C)alkoxy;
• hetCyc3 and hetCyc3a are independently a 6-membered heterocyclic ring having 1-2 ring N atoms and optionally substituted with a halogen;
• R2 is (2-4C)alkyl, cyclopropyl, OMe, I or Br;
• R3 is H or Cl;
• R4 is H or CN;
• R5 is H, halogen, OH, hetAr3, hetAr4, N-(1-3C alkyl)pyridinone, hetAr5, hetCyc4, hetCyc5C(═O)—, hetCyc6 (1-4Calkyl)-, hetCyc7 (1-4C)alkoxy, (hetCyc8)—O—, hetCyc9 (1-4C) alkoxy, (1-3 C alkoxy)(1-4C)alkoxy, hydroxy(1-4C)alkoxy, dihydroxy(2-4C)alkoxy, difluoro-amino(1-4C)alkoxy, [di(1-3 C alkyl)amino](1-4C)alkoxy, [(1-4C alkoxy)carbonyl amide]difluoro(1-4C)alkoxy, (1-4C alkyl)C(═O)NH(2-4C)alkylthio-, (1-4Calkyl)OC(═O)—, (1-4C alkyl)C(═O)—, hydroxy(1-4C)alkyl, [hydroxy(2-4C)alkyl)amino]-(1-4C)alkyl, [1-4C alkoxy)(1-4C alkyl)amino](1-4C)alkyl, [di(1-4C alkyl)amino](1-4C)alkyl, R′R″NC(═O)—, 1-6Calkylthio, benzyloxy, [hydroxy(1-4C)alkoxy](1-4C)alkoxy, or [(2-4Calkenyloxy)(1-4C)alkoxy](1-4C)alkoxy;
• hetAr3 is a 5-membered heteroaryl ring having 1-3 ring heteroatoms independently selected from N, O and S, wherein said ring is optionally substituted with one or more substituents independently selected from (1-6C)alkyl and [di(1-3C alkyl)amino]CH2—;
• hetAr4 is a 6-membered heteroaryl ring having 1-2 ring N atoms and optionally substituted with one or more substituents independently selected from (1-6C)alkyl;
• hetAr5 is a 9-membered partially unsaturated bicyclic heterocyclic ring having 3 ring N atoms and optionally substituted with one or more substituents independently selected from (1-6C)alkyl;
• hetCyc4 is a 5-7 membered saturated or partially unsaturated heterocyclic ring having 1-2 ring heteroatoms selected from N and O and at least one of said heteroatoms is N, wherein said ring is optionally substituted with one or more substituents independently selected from (1-6C)alkyl, hydroxy(1-4C)alkyl, OH and oxo;
• hetCyc5 is a 6 membered heterocyclic ring having 1-2 ring N atoms and optionally substituted with one or more substituents independently selected from (1-6C)alkyl;
• hetCyc6 is a 4-6 membered heterocyclic ring having 1-2 ring N atoms and optionally substituted with one or more substituents independently selected from (1-6C)alkyl, (1-4C)alkoxy and halogen;
• hetCyc7 is a 4-6 membered heterocycle having 1-2 ring heteroatoms independently selected from N, O and S, wherein one of said ring nitrogen atoms is optionally oxidized to N(O) and wherein said S ring atom is optionally oxidized to SO or SO2, wherein hetCyc7 is optionally substituted with one or more substituents independently selected from (1-6C)alkyl, (1-4C)alkylOC(═O)—, (1-4C)alkoxy, OH and halogen;
• hetCyc8 is a 4-6 membered heterocycle having one or two ring N atoms and optionally substituted with one or more substituents independently selected from (1-6C)alkyl and OH;
• hetCyc9 is a bridged 8-membered heterocyclic ring having 2 ring atoms selected from N and O wherein at least one of said heteroatoms is N, wherein said ring is optionally substituted with (1-6C)alkyl;
• R′ is H or (1-4C)alkyl;
• R″ is (1-4C)alkyl, hetCyc10-, amino(1-4C)alkyl, or [di(1-4C alkyl)amino](1-4C alkyl);
• and
• hetCyc10 is a 5 membered heterocycle having a ring N atom and optionally substituted with one or more substituents independently selected from (1-6C)alkyl.