N-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents

A compound of the formula:

• or a pharmaceutically acceptable salt thereof,
• wherein
• R1 is C1-C3 alkyl;
• R2 is hydrogen or C1-C3 alkyl;
• R3 is hydrogen, halogen, C1-C3alkyl, C1-C3alkoxy, trifluoromethyl, or trifluoromethoxy;
• L is absent, or is selected from the group consisting of C1-C6 alkylene which may be optionally substituted, C2-C6 alkenylene, C2-C6 alkynylene, —(CH2)p—O—(CH2)n, and —(CH2)p—O—(CH2)z—O—(CH2)n—;
• n is an integer ranging from 0 to 4;
• p is an integer ranging from 0 to 4;
• q is an integer ranging from 0 to 6
• z is an integer ranging from 1 to 4;
• D is selected from the group consisting of:
• i) (C3-C10)cycloalkyl, optionally substituted,
• ii) (C6-C10)aryl, optionally substituted,
• iii) heteroaryl, optionally substituted,
• iv) heterocyclic, optionally substituted,
• T is absent, or is —S(CH2)z—O—(CH2)n, —O—(CH2)z—S—(CH2)n, —(CH2)q—, —(CH2)n—C(O)—(CH2)p—, —(CH2)n—O—(CH2)p—, —(CH2)n—S—(CH2)p, S—C1-C6 alkylene which may be optionally substituted, —O—C1-C6 alkylene which may be optionally substituted, —O—(CH2)p—C(O)—(CH2)n—, —(CH2)p—C(O)—(CH2)q—O—(CH2)n—, —O—(CH2), —O—(CH2)n—, —O—(CH2)z—O—(CH2)z—O—(CH2)n—, —S—(CH2)z—S—(CH2)n—, —(CH2)n—SH, or —(CH2)n—OH, and;
• G is absent, or is selected from the group consisting of:
• i) (C3-C10)cycloalkyl, optionally substituted;
• ii) (C6-C10)aryl optionally substituted;
• iii) heteroaryl, optionally substituted, and;
• iv) heterocyclic, optionally substituted.