Antioxidants for use in therapy
AssigneeKarolinska Institutet Innovations AB
InventorsLars Engman, Henrik Alexander Johansson
Life of this patent
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Abstract
Compounds based on the following structures: wherein each of R1, R2, R3 and R4 is independently selected from: hydrogen, alkyl, and substituted alkyl; and each of R5, R6 and R7 is independently selected from: hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, N,N-dialkylamino, substituted N,N-dialkylamino, N-monoalkylamino, substituted N-monoalkylamino, and electron-donating substituents are useful in the treatment of disorders or conditions caused by or involving free radical-mediated or oxidative tissue damage.
Claims29
A method of antioxidant treatment of a subject in need thereof, comprising administering a therapeutically effective amount of a compound comprising formula I or formula II, or a pharmaceutically acceptable salt thereof:
- wherein each of R1, R2, R3 and R4 is independently selected from the group consisting of hydrogen, alkyl, and substituted alkyl;
- and
- each of R5, R6 and R7 is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, N,N-dialkylamino, substituted N,N-dialkylamino, N-monoalkylamino, substituted N-monoalkylamino, and electron-donating substituents.
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A pharmaceutical composition comprising:
- (a) a compound comprising formula I or formula II, or a pharmaceutically acceptable salt thereof:
- wherein each of R1, R2, R3 and R4 is independently selected from the group consisting of hydrogen, alkyl, and substituted alkyl;
- and
- each of R5, R6 and R7 is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, N,N-dialkylamino, substituted N,N-dialkylamino, N-monoalkylamino, substituted N-monoalkylamino, and electron-donating substituents;
- and
- (b) a pharmaceutically acceptable diluent, excipient or carrier.
Dependencies are inferred from the claim text.