17-hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl derivatives, methods for the production thereof and the use thereof for treating diseases

Compound of the formula I

• in which
• R1 is either defined as the R1a radical joined to the phenyl ring in the m or p position, or defined as the R1b radical joined to the phenyl ring exclusively in the m position,
• R1a is selected from the group comprising (CH2)n-R2, C(R3)2OH, CN, C(CH2OH)2R3, C(CH2OCH2)R3,
• R1b is selected from the group comprising C2-C10-acyl, CHOHalkyl,
• R2 is selected from the group comprising aryl, heteroaryl, halogen, CN, N3, OH, NHCONHR4, OCONHR4, NHCOR4,
• R3 is selected from the group comprising hydrogen, C1-C10-alkyl,
• R4 is selected from the group comprising hydrogen, C1-C10-alkyl, C2-C10-alkenyl, C7-C20-aralkyl, aryl, heteroaryl, (CH2)qCO2R5,
• n is 1 or 2,
• q is 1 to 10,
• R5 is selected from the group comprising hydrogen, C1-C10-alkyl, CH2OH,
• X is selected from the group comprising oxygen, an NOR6 or NNHSO2R6 group,
• Y is selected from the group comprising oxygen, CHR6 or NR6,
• R6 is selected from the group comprising hydrogen, C1-C10-alkyl, aryl, C7-C20-aralkyl and the salts, solvates or solvates of the salts thereof, including all crystal polymorphs, the α-, β- or γ-cyclodextrin clathrates, and the compounds encapsulated with liposomes.