Regimens for Intra-Articular Viscosupplementation
OwnerFrançois Bailleulinventor
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Abstract
The invention provides viscosupplementation methods for treating osteoarthritis and joint injury with HA-based viscosupplements, particularly viscosupplements with an intra-articular residence half-life shorter than 3 weeks. Viscosupplements for use in the methods of the invention may be further characterized in that they contain less than 20 mg/ml HA, at least 5% (w/w) of which is in a gel form, such as, e.g., hylan B. In an illustrative embodiment, hylan G-F 20 (Synvisc®) is administered in a single intra-articular knee injection of 6±2 ml.
Claims31
1-35. (canceled)
A method for treating a knee joint of a subject suffering from osteoarthritis in said joint, the method comprising a treatment regimen, the regimen being characterized by the step of administering a single administration dose, within a 24-hour period, of a viscosupplement intra-articularly into the knee joint of said subject, wherein said viscosupplement:
- is a hyaluronan (HA)-based viscosupplement that does not contain additional active components;
- comprises between 24 mg and 100 mg of HA;
- comprises a crosslinked hyaluronan (HA);
- and
- has a residence half-life in said knee joint of between 11 hours and 8.8 days;
- and
- wherein said treatment regimen does not comprise administering the viscosupplement in weekly intervals.
A method for treating a knee joint of a human subject suffering from a joint pathology, the method comprising a treatment regimen, the regimen being characterized by the step of administering a single administration dose, within a 24-hour period, of a viscosupplement intra-articularly into the knee joint of said human subject, wherein said viscosupplement:
- is a hyaluronan (HA)-based viscosupplement that does not contain additional active components;
- comprises between 24 mg and 100 mg of HA;
- comprises a crosslinked hyaluronan (HA);
- and
- has a residence half-life in said knee joint of between 11 hours and 8.8 days;
- and
- wherein said treatment regimen does not comprise administering the viscosupplement in weekly intervals.
A method for treating osteoarthritic pain in a knee joint of a human subject, the method comprising a treatment regimen, the regimen being characterized by the step of administering a single administration dose, within a 24-hour period, of a viscosupplement intra-articularly into the knee joint of said human subject wherein said viscosupplement:
- is a hyaluronan (HA)-based viscosupplement that does not contain additional active components;
- comprises between 24 mg and 100 mg of HA;
- comprises a crosslinked hyaluronan (HA);
- and
- has a residence half-life in said knee joint of between 11 hours and 8.8 days;
- and
- wherein said treatment regimen does not comprise administering the viscosupplement in weekly intervals.
Dependencies are inferred from the claim text.