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US 2012/0258923 A1Published application
BIOACTIVITY COMPOSITION OF Reevesia formosana
AssigneeKaohsiung Medical University
InventorsIh-Sheng Chen, Hsun-Shuo Chang
Life of this patent
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Abstract
A series cardenolide derivatives including structure of formula I from the root of Reevesia formosana have provided. In formula (1) and (2), where R3, R5, R10 and R16 are as defined in the specification. The derivatives compounds showed potent cytotoxicity against MCF-7, NCI-H460, and HepG2 cancer cell lines.
Claims22
A pharmaceutical composition, comprising:
- an effective amount of a pharmaceutical compound being represented by formula 1:
- wherein the R3 group is one of a hydrogen radical and a glycosyl group, the R5 group is one of a hydrogen radical and a hydroxyl group, the R10 group is one selected from a group consisting of a hydrogen radical, a hydroxyl group, a methyl radical, a formaldehyde group and a formic acid radical, and the R16 group is one of a hydrogen radical and an acetic acid radical.
A pharmaceutical composition, comprising:
- an effective amount of a pharmaceutical compound being represented by formula 2:
- wherein the R3 group is one of a hydrogen radical and a glycosyl group, the R10 group is one selected from a group consisting of a hydrogen radical, a hydroxyl group, a methyl radical, a formaldehyde group, and a formic acid radical.
A cardenolide derivative, comprising a structure of formula 1:
- wherein the R3 group is one of a hydrogen radical and a glycosyl group, the R5 group is one of a hydrogen radical and a hydroxyl group, the R10 group is one selected from a group consisting of a hydrogen radical, a hydroxyl group, a methyl radical, a formaldehyde group and a formic acid radical, and the R16 group is one of a hydrogen radical and an acetic acid radical.
A cardenolide derivative, comprising a structure of formula 2:
- wherein the R3 group is one of a hydrogen radical and a glycosyl group, the R10 group is one selected from a group consisting of a hydrogen radical, a hydroxyl group, a methyl radical, a formaldehyde group, and a formic acid radical.
Dependencies are inferred from the claim text.