Polypeptoid pulmonary surfactants
AssigneesAnnelise E. Barron, Chiron Corporation
InventorsAnnelise E. Barron, Ronald N. Zuckermann, Cindy W. Wu
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Abstract
The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distress of the lungs. The spreading agents are sequence-specific oligomers, including retrosequence-specific oligomers, based on a peptide backbone, that are designed as analogs of surfactant protein-B or surfactant protein-C.
Claims17
An SP-C protein-analog compound comprising an N-terminal component comprising at least 2 residues selected from N-substituted glycine residues Noc, Npm and Nhd, and Phe and combinations thereof;
- a sequence selected from ProValHisLeuLysArg (SEQ ID NO:
- 1) and sequences wherein at least one said sequence residue is replaced with an N-substituted glycine residue, said N-substituent the α-carbon moiety of said replaced residue;
- and a C-terminal component comprising at least about 12 N-substituted glycine residues selected from Npm, Nspe and Nssb residues and combinations thereof.
An SP-C protein-analog compound comprising an N-terminal component comprising at least 2 residues selected from N-substituted glycine residues Noc, Npm and Nhd and combinations thereof;
- a peptoid sequence NProNValNHisNLeuNLysNArg;
- and a C-terminal component comprising about 12- about 20 N-substituted glycine residues selected from Npm, Nspe and Nssb residues and combinations thereof.
An SP-C protein-analog compound comprising an N-terminal component comprising 2 residues selected from N-substituted glycine residues Noc, Npm and Nhd and combinations thereof;
- a peptoid sequence NProNValNHisNLeuNLysNArg;
- and a C-terminal component comprising 12-14 N-substituted glycine residues selected from Npm, Nspe and Nssb residues and combinations thereof.
Dependencies are inferred from the claim text.