Peripheral Administration of Proteins Including TGF-beta Superfamily Members for Treatment of Systemic Disorders and Disease

A method of systemic treatment of an injured or diseased tissue, the method comprising the step of:

• providing to a peripheral administration site a composition comprising a biologic agent, whereupon the biologic agent is delivered in an amount effective to treat the injured or diseased tissue.

A method of treatment of an injured or diseased tissue, the method comprising the step of:

• administering to a peripheral administration site a composition comprising a biologic agent, and
• delivering to a peripheral intravenous delivery site the composition such that intima tissue integrity at the delivery site is substantially uncompromised
• whereupon the biologic agent is in an amount effective to treat the injured or diseased tissue.

A method for treating a disease in a patient by systemically administering a bone morphogenetic protein to a patient in need thereof, the method comprising the step of:

• administering the bone morphogenetic protein to the patient at an administrative site via a vascular access structure healed into the patient, wherein the administration site is peripheral and the bone morphogenetic protein is delivered to the patient at a peripherally located delivery site at least one cm from the administration site.

A composition suitable for ameliorating an injury or disease, the composition comprising:

• a biologic agent in an amount effective to ameliorate an injury or disease;
• and, a venipuncture apparatus for administering said agent to a blood vessel, wherein the apparatus is adapted to deliver said agent to a trauma-free region of the blood vessel.

A kit for use in systemically administering a bone morphogenetic protein to a patient in need thereof comprising:

• a bone morphogenetic protein;
• and
• a peripheral vascular access structure for peripheral implantation in said patient.

A kit for use in systemically administering a bone morphogenetic protein to a patient in need thereof comprising:

• a bone morphogenetic protein;
• and
• instructions for systemically administering the bone morphogenetic protein to the patient via peripheral administration.