Pharmaceutical compositions and methods for delivering such compositions
AssigneeNektar Therapeutics
InventorsMichael D. Bentley, Sean M. Culbertson, Samuel P. McManus
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Abstract
The present invention provides pharmaceutical compositions comprising a pharmaceutically acceptable excipient and a conjugate having a degradable linkage. The conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods for delivering such compositions are also provided.
Claims21
A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a conjugate of the following formula:
- wherein:
- POLY1 is a first water-soluble polymer;
- POLY2 is a second water-soluble polymer;
- X1 is a first spacer moiety;
- X2 is a second spacer moiety;
- H□ is an ionizable hydrogen atom;
- R1 is H or an organic radical;
- R2 is H or an organic radical;
- and
- Y1 is O or S;
- Y2 is O or S;
- and
- D is a residue of a biologically active agent.
The pharmaceutical composition of claim 66, wherein the liquid diluent is selected from the group consisting of bacteriostatic water for injection, dextrose 5% in water, phosphate-buffered saline, Ringer's solution, saline solution, sterile water, deionized water, and combinations thereof.
Dependencies are inferred from the claim text.