Method of Determining Predisposition to Scoliosis
AssigneeAxial Biotech, Inc.
InventorsMichael R. Schramm, James W. Ogilvie, Lesa M. Nelson, Kenneth Ward, Rakesh N. Chettier
Life of this patent
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Abstract
The present invention relates to novel genetic markers associated with scoliosis, risk of developing scoliosis and risk of scoliosis curve progression, and simplified methods and materials for determining whether a human subject has scoliosis, is at risk of developing scoliosis or is at risk of scoliosis curve progression.
Claims21
A method for use in determining risk of spine curve progression in a human subject having idiopathic scoliosis, said method comprising the steps of:
- assaying and detecting at least one scoliosis spine curve progression associated biological marker in a biological sample of said subject, and
- deriving a value of risk of spine curve progression of said subject by performing a calculation based on said at least one detected scoliosis spine curve progression associated biological marker, wherein said derived value defines an increased risk of scoliosis spine curve progression compared to a control value.
A method for use in determining risk of spine curve nonprogression in a human subject having idiopathic scoliosis, said method comprising the steps of:
- assaying and detecting at least one scoliosis spine curve nonprogression associated biological marker in a biological sample of said subject, and
- deriving a value of risk of spine curve nonprogression of said subject by performing a calculation based on said at least one detected scoliosis spine curve nonprogression associated biological marker, wherein said derived value defines an decreased risk of scoliosis spine curve progression compared to a control value.
A method for use in determining risk of spine curve progression or nonprogression in a human subject having idiopathic scoliosis, said method comprising the steps of:
- diagnosing at least one scoliosis related clinical factor in said subject,
- assaying and detecting at least one scoliosis spine curve associated biological marker in a biological sample of said subject, wherein said at least one scoliosis curve progression associated biological marker defines the minor allele of at least one of the biological markers of table 1 (rs12604939, rs1294570, rs17623155, rs4786851, rs9826626, rs10515953, rs12599502, rs1851027, rs651662, and rs987862), and a biological marker in complete linkage disequilibrium with a biological marker of table 1, and
- deriving a value of risk of spine curve change of said subject by performing a calculation based on said at least one detected scoliosis spine curve associated biological marker, wherein if the odds ratio (OR) of said at least one scoliosis spine curve associated biological marker is greater than 1.0, said derived value defines an increased risk of scoliosis spine curve progression compared to a control value, and wherein if the odds ratio (OR) of said at least one scoliosis spine curve associated biological marker is less than 1.0, said derived value defines a decreased risk of scoliosis spine curve progression compared to a control value.
Dependencies are inferred from the claim text.