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AssigneesSRU Biosystems, Inc., The Board of Trustees of the University of Illinois
InventorsMeng Lu, Chun Ge, Brian T. Cunningham, Stephen Schulz
Estimating the term…
A label-free biosensor detection arrangement incorporating an external cavity laser (ECL) includes a tunable lasing element (e.g. an antireflection coated laser diode or semiconductor optical amplifier) and a narrow bandwidth resonant reflectance filter as the wavelength-selective element for the tunable lasing element. A sample is deposited on the surface of the resonant reflectance filter containing a biological material. The wavelength emitted by the external cavity laser is continuously tunable by binding interactions between the biological material and the resonant reflectance filter or adsorption of the biological material present in the sample on resonant reflectance filter. The narrow bandwidth resonance reflectance filter can take the form of photonic crystal (PC), a Bragg stack, or a Brag fiber reflection filter.
A biosensor detection arrangement forming an external cavity laser comprising, in combination:
The arrangement of claim 14, wherein the relatively high index of refraction material comprises at least one of TiO, TaO, HfO, SiN, ZnS.
A photonic crystal enhanced fluorescence biosensor detection arrangement forming an external cavity laser comprising, in combination:
A method of detection biomolecular interactions, comprising the steps of:
A biosensing method, comprising the steps of:
Dependencies are inferred from the claim text.