Method of delivering rna interference and uses thereof
AssigneeImmune Disease Institute, Inc.
InventorsJudy Lieberman, Erwei Song
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Abstract
The invention provides a method of RNA interference, which comprises contacting the cell with a fusion protein-double stranded RNA complex, the complex comprising the double stranded RNA segment containing a double stranded RNA of interest and a fusion protein, the fusion protein comprising (1) a targeting moiety, which will specifically binds to a site on a target cell, and (2) a binding moiety, which will bind to the double stranded RNA, wherein the double stranded RNA segment initiates RNA interference in the cell.
Claims1
A method of RNA interference in a cell, the method comprising contacting the cell with a fusion protein-double stranded RNA complex, the complex comprising:
- a) an RNA molecule comprising a double stranded RNA segment, wherein one of the strands is complementary and the other strand identical to an RNA interference target RNA;
- and
- b) a fusion protein, comprising (1) a targeting moiety, which specifically binds to a site on a target cell, and (2) a binding moiety, which binds to the double stranded RNA segment,
- wherein the double stranded RNA segment initiates RNA interference in the cell.
Dependencies are inferred from the claim text.