Novel Therapeutical Tools and Methods for Treating Blindness
AssigneeNovartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Resear
InventorsDavid BALYA, Rita HABAR, Volker BUSSKAMP, Pamela LAGALI, Botond ROSKA
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Abstract
The present inventions relates to the use of an isolated nucleic acid molecule comprising a nucleotide sequence coding for a hyperpolarizing light-gated ion channel or pump gene from an archeon or for a light-active fragment of said gene, or the nucleotide sequence complementary to said nucleotide sequence, for treating or ameliorating blindness. The light-gated ion channel or pump gene can be a halorhodopsin gene.
Claims15
An isolated nucleic acid molecule comprising a nucleotide sequence coding for a hyperpolarizing light-gated ion channel or pump gene from an archeon or for a light-active fragment of said gene, or the nucleotide sequence complementary to said nucleotide sequence, for use in treating or ameliorating blindness.
An isolated nucleic acid molecule useful for treating blindness comprising a nucleic acid sequence coding for a hyperpolarizing light-gated ion channel or pump gene and a nucleic acid sequence coding for a depolarizing light-gated ion channel or pump gene.
Dependencies are inferred from the claim text.