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US 2012/0258513 A1Published application
Selective Neuronal Nitric Oxide Synthase Inhibitors
AssigneeNorthwestern University
InventorsRichard B. Silverman, Haitao Ji, He Huang
Life of this patent
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Abstract
Compounds and related methods for selective inhibition of neuronal nitric oxide synthase over inducible and endothelial isoforms, such compounds as can provide reduced cationic character and enhanced bioavailability.
Claims35
A nitric oxide synthase inhibitor compound of a formula
- wherein n is selected from 0 and 1;
- Y is selected from CH2, O, NH, CH2O, CH2NH, CH2CH2 and CH═CH moieties;
- X is selected from N and CH;
- and R1 and R2 are independently selected from H, methoxy, fluoro, chloro,and mono-, di- and trifluoromethyl, and mono-, di, and trichloromethyl substituents, and combinations thereof, and a salt thereof.
1 more element
A nitric oxide synthase inhibitor compound of a formula
- wherein Y is selected from CH2CH2 and CH═CH moieties;
- and R1 and R2 are independently selected from H, Cl and F, and a salt thereof.
A nitric oxide synthase inhibitor compound of a formula
- wherein Y is selected from CH2CH2 and CH═CH moieties;
- R3 is selected from H and CH3;
- and R4 is selected from H and NH2, and a salt thereof.
A nitric oxide synthase inhibitor compound of a formula
- wherein Ar is selected from naphthalenylene and isoquinolinylene moieties;
- X is selected from CH and N;
- R1 is selected from H and CH3;
- and R2 is independently selected from H and NH2, and a salt thereof.
1 more element
Dependencies are inferred from the claim text.