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US 2012/0258482 A1Published application
Pcna methyltransferase
AssigneeIndiana University Research and Technology Corporation
InventorsDerek J. Hoelz, Robert J. Hickey, Linda H. Malkas
Life of this patent
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Abstract
Proliferating cell nuclear antigen (PCNA)-dependent glutamate methyltransferases are disclosed that can methylesterify one or more glutamic acid or aspartic acid residues of PCNA.
Claims13
A purified methyltransferase, where said methyltransferase methylesterifies one or more acidic amino acid residues of proliferating cell nuclear antigen (PCNA);
- has a molecular weight of approximately 50 kDa;
- and has a secondary structure comprising 9 α-helices in its N-terminus and seven a-helices and nine β-sheets in its C-terminus.
A method for diagnosing cancer, said method comprising
- obtaining a biological test sample from a patient;
- conducting an assay for proliferating cell nuclear antigen (PCNA) targeted methyltransferase activity;
- and
- measuring the amount of proliferating cell nuclear antigen (PCNA) that has been methylesterified by said biological test sample relative to a standard value.
1 more element
(canceled)
Dependencies are inferred from the claim text.