Methods for the detection of jc polyoma virus
AssigneeBiogen Idec MA Inc.
InventorsLeonid Gorelik, Alexey Lugovskoy
Life of this patent
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Abstract
Methods and compositions for determining whether a subject is at risk for PML, including subjects being treated with immunosuppressants, by determining whether the subject harbors a JCV variant with reduced binding for sialic acid relative to a normal JCV, are presented. Furthermore, combinations of JCV-VP1 sequence variations that are associated with PML and that can be used as a basis of an assay for identifying subjects susceptible to PML, subjects with PML (e.g., early stage PML), or subjects at risk of developing PML in response to an immunosuppressive treatment are provided.
Claims22
A method comprising:
- interrogating a biological sample from a subject for at least one indicium of a variant JCV VP1 capsid protein that comprises a substitution of amino acid residue 122, and
- wherein the subject is determined to have an increased susceptibility for PML if the sample comprises the at least one indicium.
(canceled)
Dependencies are inferred from the claim text.