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US 2012/0258442 A1Published application
Determining tumor origin
Assigneebio Theranostics, Inc.
InventorsMark Erlander, Xiao-Jun Ma
Life of this patent
Estimating the term…
Abstract
The disclosure provides methods for the use of gene expression measurements to classify or identify among 54 cancer types in samples obtained from a subject in a clinical setting, such as in cases of formalin fixed, paraffin embedded (FFPE) samples.
Claims17
A method of amplifying transcribed sequences for classifying a cell containing sample as containing tumor cells of a type of tissue, said method comprising
- producing cDNA copies of 50 or more transcribed sequences from cells in a cell containing sample obtained from a human subject,
- amplifying said cDNA copies to produce amplified molecules,
- comparing said expression levels of 50 or more transcribed sequences to expression levels of the same 50 or more transcribed sequences in a plurality of known tumor types comprising one or more known tumor tissues selected from adrenal-cortical tumor, tumor of the salivary gland, squamous cell carcinoma, neuroendocrine-pancreas cancer, merkel cell carcinoma, lung carcinoid, primitive neuroectodermal tumor, sex cord stromal tumor, thymic carcinoma/thymoma, adenocarcinoma of urinary bladder, and squamous cell carcinoma of urinary bladder;
- and
- classifying the sample as containing or not containing tumor cells of a tumor type or tissue in said plurality.
2 more elements
Dependencies are inferred from the claim text.