Polymer for Controlling Delivery of Bioactive Agents and Method of Use

Abstract

A medical device includes a base material and chlorhexidine or a pharmaceutically acceptable salt thereof disposed in the base material sufficient to reduce microbial growth. The base material includes a polymer having a silicone monomer and a urethane monomer. To make the medical device having an antimicrobial agent, a silicone-urethane-carbonate polymer is dissolved in Dimethylformamide/Tetrahydrofuran (DMF/THF) to generate a coating solution, a chlorhexidine or a pharmaceutically acceptable salt thereof is mixed into the coating solution, a base material is coated with the coating solution, and the coating solution is dried to remove the solvent. The chlorhexidine is present in concentration sufficient to reduce microbial growth.

Dependencies are inferred from the claim text.