Macronutrient sensitivity
OwnerGraeme John Smith, Nick Argyrou +2inventors
InventorsGraeme John Smith, Nick Argyrou, Helen Argyrou, Harry Banaharis
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Abstract
The present invention relates to a method and a kit for identifying a subjects macronutrient sensitivity. The method involves assaying a genetic sample from the subject to determine a polymorphism profile, analysing the polymorphism profile to identify risk alleles and determining the macronutrient sensitivity based on the number of risk alleles present. This information can be used for determining an appropriate diet to induce satiety, formulating a diet for inducing satiety, or for treating a range of medical complaints associated with metabolism.
Claims15
1-31. (canceled)
A method for determining a genetic predisposition of a subject to reduced satiety after consuming carbohydrate or lipid in excess of an optimal level for their genotype, comprising:
- a) assaying a genetic sample from the subject for the presence of at least two polymorphisms associated with carbohydrate sensitivity and at least two polymorphisms associated with lipid sensitivity to obtain a polymorphism profile;
- b) analysing the polymorphism profile to identify predisposition alleles;
- c) calculating predisposition scores for carbohydrate sensitivity and lipid sensitivity from the identified predisposition alleles;
- and
- d) classifying the subject's genetic predisposition to reduced satiety after consuming carbohydrate or lipid in excess of an optimal level for their genotype based on the predisposition scores.
A kit for determining a genetic predisposition of a subject to reduced satiety after consuming carbohydrate or lipid in excess of an optimal level for their genotype, comprising a reagent for assaying a genetic sample from the subject for the presence of at least two polymorphisms associated with carbohydrate sensitivity and at least two polymorphisms associated with lipid sensitivity to obtain a polymorphism profile;
- wherein the at least two polymorphisms associated with carbohydrate sensitivity are selected from polymorphisms in genes selected from the group consisting of TCF7L2, FTO, KIR6.2 (KCJN11), PPARG, IGF2BP2, CDKN2B, SLC30A8, HHEX, CDKAL1, WFS1, NOTCH2, JAZF1, CDC123, G6PC2 and APOA5;
- and
- wherein the at least two polymorphisms associated with lipid sensitivity are selected from polymorphisms in genes selected from the group consisting of APOE, APOB, PSRC1, LDLR, CETP, LPL, PCSK9, FABP2 and LEPR.
Dependencies are inferred from the claim text.