Parp inhibitors for the treatment of cipn

A method for treating chemotherapy-induced peripheral neuropathy in a subject, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I)

• or a pharmaceutically acceptable salt or solvate thereof, wherein
• R1, R2, and R3 are independently selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxycarbonyl, alkyl, alkynyl, cyano, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, nitro, NRARB, and (NRARB)carbonyl;
• A is a nonaromatic 4, 5, 6, 7, or 8-membered ring that contains 1 or 2 nitrogen atoms and, optionally, one sulfur or oxygen atom, wherein the nonaromatic ring is optionally substituted with 1, 2, or 3 substituents selected from the group consisting of alkenyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkynyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, cyano, haloalkoxy, haloalkyl, halogen, heterocycle, heterocycloalkyl, heteroaryl, heteroarylalkyl, hydroxy, hydroxyalkyl, nitro, NRCRD, (NRCRD)alkyl, (NRCRD)carbonyl, (NRCRD)carbonylalkyl, (NRCRD)sulfonyl, and oxo;
• and
• RA, RB, RC, and RD are independently selected from the group consisting of hydrogen, alkyl, and alkycarbonyl.