Demineralized bone matrix compositions and methods
AssigneeWarsaw Orthopedic, Inc.
InventorsKeyvan Benham, Guobao Wei, James A. Beisser
Life of this patent
Estimating the term…
Abstract
Bone matrix compositions and, more specifically, demineralized bone matrix (DBM) having increased osteoinductive capacity and methods for its production are provided. Specifically, DBM derived from cortical bone from the periosteal layer of bone are provided. Compositions comprising a disproportionate amount of DBM prepared from bone derived from the periosteal and/or middle layer of bone are provided. Preparations of and methods of use of periosteal DBM compositions are disclosed.
Claims20
A demineralized bone matrix composition comprising a disproportionate higher percentage of cortical bone derived from a periosteal layer as compared to cortical bone derived from a non-periosteal layer.
An allograft composition comprising demineralized bone matrix wherein the demineralized bone matrix is comprised of a disproportionate higher percentage of cortical bone derived from a periosteal layer as compared to cortical bone derived from a non-periosteal layer.
A demineralized bone matrix composition comprising a disproportionate higher percentage of demineralized bone derived from a periosteal layer as compared to cortical bone derived from a non-periosteal layer wherein the demineralized bone matrix composition has no exogenous growth factor or demineralized bone matrix (DBM) extract, and wherein the demineralized bone matrix composition has an osteoinductive factor content greater than demineralized bone matrix comprising bone derived from the non-periosteal layer as compared to demineralized bone matrix comprising bone derived from the periosteal layer.
A method for producing an osteoinductive composition, the method comprising:
- obtaining cortical bone that comprises a disproportionate higher percentage of demineralized bone from a periosteal layer than cortical bone derived from a non-periosteal layer;
- and demineralizing the cortical bone.
A composition comprising demineralized cortical bone wherein the composition has higher osteoinductive activity than cortical demineralized bone prepared from aggregate long bones of the same donor, wherein the increase in osteoinductive activity is not attributed to addition of growth factors or treatment with enzymes, but is a consequence of selective demineralization of a specific region of a long bone or a specific type of long bone.
20-22. (canceled)
Dependencies are inferred from the claim text.