Controlled delivery of molecules from a biointerface
AssigneeEmpire Technology Development LLC
InventorMark A. Tapsak
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Abstract
Disclosed are methods and apparatuses for delivery of bioactive molecules. The drug delivery systems include an implantable medical device which significantly reduces or suppresses adverse biological responses associated with implantable devices and also promotes vascularization in tissues surrounding the implanted device. The disclosure also relates to drug delivery systems designed to vary the rate of delivery of bioactive molecules with a change in the physiological environment.
Claims21
A drug delivery system comprising an implantable medical device configured to include a biointerface comprising a polymer and a bioactive molecule attached to the polymer via a silyl ether linker.
A method comprising releasing a bioactive molecule from a drug delivery system at a pH of less than 7, wherein the drug delivery system comprises an implantable medical device configured to include a biointerface comprising a polymer and a bioactive molecule attached to the polymer via a silyl ether linker.
Dependencies are inferred from the claim text.