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AssigneesNovozymes Biopolymer A/S, Evonik Goldschmidt GmbH
InventorsHans Henning Wenk, Mike Farwick, Sandra Nattland, Ursula Maczkiewitz, Birgitte Moelholm Malle
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The present invention relates to methods of producing crosslinked hyaluronic acid microbeads, as well as the produced microbeads, said method comprising the steps of: (a) providing an aqueous alkaline solution comprising hyaluronic acid, or a salt thereof; (b) forming microdroplets having a desired size from the mixed solution of step (a) in an organic or oil phase to form a water in organic or water in oil (W/O) emulsion, wherein the amount of oil phase used is of from 20 to less than 50% by weight based on the sum of oil phase and water; (c) adding a solution comprising a crosslinking agent to the emulsion, whereby the reaction of hyaluronic acid with the crosslinking agent takes place to provide crosslinked hyaluronic acid microbeads; and (d) optionally working up the dispersion of crosslinked hyaluronic acid microbeads obtained in step (c).
Microbeads comprising hyaluronic acid, or a salt thereof, crosslinked with a crosslinking agent, wherein said crosslinking agent is divinylsulfone, glycerol diclycidyl ether or 1,4-butanediyl diglycidyl ether, and wherein said microbeads have a polydispersity in which greater than 97% of the particles are less than or equal to a tenfold of a maximum of particle size distribution.
A composition comprising microbeads comprising hyaluronic acid, or a salt thereof, crosslinked with a crosslinking agent, wherein said crosslinking agent is divinylsulfone, glycerol diclycidyl ether or 1,4-butanediyl diglycidyl ether, and wherein said microbeads have a polydispersity in which greater than 97% of the particles are less than or equal to a tenfold of a maximum of particle size distribution.
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Dependencies are inferred from the claim text.