SUPPRESSORS OF CpG OLIGONUCLEOTIDES AND METHODS OF USE
AssigneesDepartment of Health and Human Services, The Government of the United States of America as represented by the Secretary of the
InventorsDennis M. Klinman, Rainald Zeuner, Mayda Gursel, Ihsan Gursel, Daniela Verthelyi
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Abstract
The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
Claims20
An isolated oligodeoxynucleotide comprising the nucleic acid sequence set forth as SEQ ID NO:
- 3, wherein the oligodeoxynucleotide is modified to prevent degradation and wherein the oligodeoxynucleotide is at most 120 nucleotides in length, has a CD value of at least 2.9 and suppresses an immune response.
Dependencies are inferred from the claim text.