Rna sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles
AssigneeColey Pharmaceutical GmbH
InventorsMarion Jurk, Jorg Vollmer
Life of this patent
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Abstract
Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α.
Claims8
1-80. (canceled)
A method for treating an allergic condition, comprising administering to a subject having an allergic condition an effective amount of an RNA nucleotide polymer selected from:
- A-A-A-C-G-C-U-C-A-G-C-C-A-A-A-G-C-A-G (SEQ ID NO 3);
- A-A-A-C-G-C-U-C-A-C-C-C-A-A-A-G-C-A-G (SEQ ID NO 17);
- A-A-A-C-A-C-U-C-A-G-C-C-A-A-A-G-C-A-G (SEQ ID NO 22);
- and
- A-A-A-C-C-C-U-C-A-G-C-C-A-A-A-G-C-A-G (SEQ ID NO 23);
- wherein the polymer comprises a phosphodiester backbone.
(canceled)
85-106. (canceled)
The method according to any one of the preceding claims, wherein the polymer is administered in association with a pharmaceutical composition.
Dependencies are inferred from the claim text.