Methods and compositions for modulation of histone ubiquitination
OwnerC. W. Xu, Zhen Gaoinventors
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Abstract
Provided are methods and compositions for inhibiting mono-ubiquitination of a histone in a cell. Also provided are methods and compositions for inducing senescence in a cell. Additionally provided are methods and compositions for treatment of cancer, including glioma. In particular, these methods and compositions may include an inhibitor of a ubiquitin ligase.
Claims23
A method of inducing senescence in a cell comprising contacting the cell with an inhibitor of mono-ubiquitination of a histone.
A method of inhibiting mono-ubiquitination of a histone in a cell comprising contacting the cell with a negative modulator of a ubiquitin ligase.
A method of treatment for cancer comprising administration to a subject in need of treatment a composition comprising a negative modulator of a ubiquitin ligase in an amount effective to inhibit mono-ubiquitination of a histone in cancer cells in the subject.
A composition effective for the treatment of cancer comprising at least one negative modulator of a ubiquitin ligase.
Dependencies are inferred from the claim text.