Compounds and methods for the treatment of renal disease
AssigneeOpsona Therapeutics Limited
InventorsMark Heffernan, Luke O'Neill, Peter McGuirk, Brian Keogh, Christopher Locher
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Abstract
The present invention provides compounds and methods for the treatment and prophylaxis of renal disease and inflammation. In particular the invention provides methods for the treatment of kidney disease and failure through the administration of compounds which function as inhibitors of TLR2 function and expression.
Claims28
A method of reducing one or more biological activities of Toll like receptor 2 (TLR2) in a TLR2 expressing cell or tissue implicated in renal disease or inflammation, comprising:
- contacting the cell or tissue with an antibody which acts as an antagonist of TLR2 activity, in an amount sufficient to reduce one or more biological activities of TLR2 in the cell or tissue.
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A method for the treatment and/or prophylaxis of a renal disorder, the method comprising the step of:
- administering a therapeutically effective amount of an antibody or a binding fragment thereof, which is an agonist of the function of Toll-like Receptor 2,
- to a subject in need of such treatment.
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Dependencies are inferred from the claim text.