Chimeric anti-ricin antibody
AssigneesEtat Francais Represente Par Le Delegue General Po, Lfb Biotechnologies
InventorsPhilippe Thullier, Alexandre Fontayne
Life of this patent
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Abstract
A chimeric monoclonal antibody targeted at ricin, in which the light chain and heavy chain are such that: the constant region of the light chain and the constant region of the heavy chain are essentially made up respectively of the constant region of the light chain and the constant region of the heavy chain of human immunoglobulin, the variable region of the light chain and the variable region of the heavy chain include respectively the variable region of the light chain and the variable region of the heavy chain of macaque immunoglobulin, the monoclonal antibody not substantially inducing an immune response against chimeric antibodies.
Claims18
Chimeric monoclonal antibody targeted at ricin, in which the light chain and the heavy chain are such that:
- the constant region of the light chain is essentially made up of the constant region of the light chain of a human immunoglobulin,
- the constant region of the heavy chain is essentially made up of the constant region of the heavy chain of a human immunoglobulin,
- the variable region of the light chain includes the variable region of the light chain of a macaque immunoglobulin and,
- the variable region of the heavy chain includes the variable region of the heavy chain of a macaque immunoglobulin
- the said monoclonal antibody not substantially inducing an immune response against chimeric antibodies.
Dependencies are inferred from the claim text.