Inhibitors of guanine exchange factors and their use as anticancer drugs
AssigneesUniversite Montpellier 2 Sciences Et Techniques, Centre National De La Recherche Scientifique
InventorsAnne Debant, Susanne Schmidt, Nathalie Bouquier, Sylvie Fromont
Life of this patent
Estimating the term…
Abstract
A peptide including the amino acids sequence X9CGYX13X14AX16X17X18MX20X21X22X23X24X25X26X27CPLCX32X33, a nucleic acid coding for the peptide, and/or a recombinant vector including the nucleic acid for the preparation of a drug intended for the treatment of cancer.
Claims21
A method for treating cancer, comprising administering to a subject in need there of a therapeutically effective amount of a peptide comprising or consisting of the following amino acid sequence SEQ ID NO:
- 2,
- X9CGYX13X14AX16X17X18MX20X21X22X23X24X25X26X27CPLC
- X32X33
- wherein bold underlined amino acids represent essential amino acids for the activity of said peptide, and wherein X9, X13, X14, X16, X17, X18, X20, X21, X22, X23, X24, X25, X26, X27, X32 and X33 represent any amino acids with the proviso that said peptide does not comprise or consist of the amino acid sequence SEQ ID NO:
- 1.
Isolated peptide comprising or consisting of the amino acid sequence SEQ ID NO:
- 3,
- ICGYX13LAX16X17X18MLGPX23X24RVX27CPLCX32P
- wherein bold underlined amino acids represent essential amino acids for the activity of said peptide, and wherein X13, X16, X17, X18, X23, X24, X27 and X32 represent any amino acids, with the proviso that said amino acid sequence does not comprise or consist of the amino acids sequence SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.